Genotoxic Evaluation of a Chloroalcohol Resulting From Acid Degradation of an Oral Pharmaceutical Containing an Oxetane Ring

Time

Wed, Jun 26 11:45AM
W 17

Title

Genotoxic Evaluation of a Chloroalcohol Resulting From Acid Degradation of an Oral Pharmaceutical Containing an Oxetane Ring

Abstract Summary

The neat chloroalcohol degradant was evaluated in: 1) Bacterial mutagenicity (Ames) assay; 2) in vitro chromosomal aberration (CAB) assay in CHO cells; 3) in vivo mouse bone marrow micronucleus assay; and 4) in vivo mouse Comet assay to detect DNA strand breakage in the liver, stomach and duodenum.

Poster Presenter

Andrew J. Dropsey
MSc,
Consultant Toxicologist,
Eli Lilly and Company
United States

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