Spontaneous Ventricular Arrhythmias in Early Clinical Trials: a Report from a Single and Repeated Ascending Dose Study

Time

Tue, Jun 25 11:45AM
T 26

Title

Spontaneous Ventricular Arrhythmias in Early Clinical Trials: a Report from a Single and Repeated Ascending Dose Study

Abstract Summary

The primary objective of the single centre clinical trial was to assess the safety and tolerability of single (SAD, seven dose levels) and repeated (MAD, five dose levels for seven days) ascending doses of a compound compared to placebo when administered to male HVs. There were two Holters for each subject in off-drug conditions, one at screening and one at Day -1. VA occurrence time was compared to individual maximum drug concentrations (Cmax)

Poster Presenter

Antonio Ferrari
MD,
Corporate Cardiac Leader,
Chiesi Farmaceutici S.P.A.
Italy

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